Keep an eye on Closely (2)pentobarbital will decrease the extent or influence of oliceridine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. If coadministration which has a CYP3A4 inducer is necessary, consider rising oliceridine dose until finally secure drug effects are attained; observe for indications of opioid withdrawal.
pentobarbital will lessen the level or outcome of tadalafil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Stay clear of mixture in pulmonary HTN patients. For people with ED, watch response to tadalafil carefully due to potential for diminished efficiency.
pentobarbital will decrease the level or impact of ramelteon by impacting hepatic enzyme CYP2C9/10 metabolism. Slight/Significance Unidentified.
pentobarbital will minimize the extent or effect of irinotecan by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
pentobarbital will lower the level or outcome of darifenacin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
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pentobarbital will reduce the level or outcome of bosentan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unidentified.
Contraindicated. Coadministration of doravirine with a strong CYP3A inducer may possibly lower doravirine plasma concentrations and/or effects. Likely for loss of virologic reaction and feasible resistance to doravirine.
pentobarbital will lessen the level or impact of tamoxifen by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
With therapeutic doses of TCAs, barbiturates raise metabolism and reduce blood concentrations of TCAs.
With therapeutic doses of TCAs, barbiturates raise metabolism and decrease blood concentrations of TCAs.
With therapeutic doses of TCAs, barbiturates improve metabolism and decrease blood concentrations of TCAs.
Observe Closely (1)pentobarbital will reduce the extent or impact of benzhydrocodone/acetaminophen by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch check here Intently. Warning when discontinuing CYP3A4 inducers that happen to be coadministered with benzhydrocodone (prodrug of hydrocodone); plasma concentrations of hydrocodone may perhaps maximize and may result in likely lethal respiratory despair.
pentobarbital will decrease the extent or influence of isradipine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unfamiliar.